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Extravasation Extravasation is defined as the leakage of solutions from the vein. Symptoms of extravasation reactions range from: - Pain
- Self-limited, localised inflammation to full-thickness necrosis
- Ulceration and sloughing of skin and underlying structures
Lesions may expand in size over a period of weeks or months and most heal poorly and slowly. In extensive ulceration, plastic surgery may be needed to remove trapped drug from the tissue and then be followed by skin grafting.
The extent of symptoms also depends on the: - Infusion site
- Condition of the tissue
- Concentration and volume of the vesicant
- Any treatments that may have been applied
The ulceration may not appear for several days or even weeks and may continue to worsen for months, probably because of drug diffusion into adjacent tissue.
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Useful link:
- Savene® and Totect®
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Photo with permission from Seppo W. Langer, Copenhagen, Denmark |
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Cancer